Carsten Burkhardt's Web Project Paeonia - The Peony Library

ano_finnland7 index 0602 boreas2

Paeonia-Literatur 2002

Barzilay A, Zemah H, Kamenetsky R, Ran I (2002) Annual life cycle and floral development of 'Sarah Bernhardt' peony in Israel. HortScience 37, 303-303.

Burkhardt, C Paeonien-Rundbrief der Fachgruppe Päonien der Gesellschaft der Staudenfreunde eV:

Burkhardt, Carsten, Kiehn, Michael (2002) Strauch-Pfingstrosen, Geschichte – Botanik – Artenschutz Der Palmengarten, 66 (2):144-151


Dharmananda, Subhuti, White Peony, Red Peony, and Moutan: Three Chinese Herbs Derived from Paeonia August 2002

EasonJ: Effect of storage temperature and harvest bud maturity on bud opening and vase life of Paeonia lactiflora NEW ZEALAND JOURNAL OF CROP AND HORTICULTURAL SCIENCE Vol.30 Iss.1 P.61-68 (2002)

Guo BL, Basang D, Xiao PG, Hong DY. [Research on the quality of original plants and material medicine of Cortex Paeoniae] [Article in Chinese] Zhongguo Zhong Yao Za Zhi. 2002 Sep;27(9):654-7. [OBJECTIVE: To study the contents of main chemical compounds, such as, paeonol, paeoniflorin and their similar compounds in structure in Paeonia ostii and P. suffruticosa, and to find their quality difference. METHOD: HPLC was used. The contents of paeoniflorin and paeonol in 9 collected samples, 5 from P. ostii and 4 from P. suffruticosa, and 6 herb samples bought from different areas were analyzed. The rough contents of 3 paeonol similar compounds and 2 paeoniflorin similar compounds were investigated. RESULT AND CONCLUSION: 1. There is no obvious difference in the contents of paeonol and paeonoflorin and the constitution of other main compounds between P. ostii and P. suffruticosa. Since they belong to different botanic species, it is suggested that both P. ostii and P. suffruticosa should be recorded in Chinese Pharmacopoeia as the origin of Cortex Paeoniae. 2. The glucosides of paeonol might change to paeonol in the course of the collecting and processing of the herb. Therefore when the contents of paeonol is used as the standard to evaluate the quality of the material and patent medicine, the attention should be paid to the transformation mentioned above.] Institute of Medicinal Plant, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China.

Kim HJ, EJ Chang, SJ Bae, SM Shim, HD Park, CH Rhee, JH Park, SW Choi : Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactiflora ARCHIVES OF PHARMACEUTICAL RESEARCH Volume: 25 Issue: 3 Page: 293-299 Year: 2002 [Summary:Cytotoxic and antimutagenic effects of a novel cis-epsilon-viniferin and five known stilbenes, transresveratrol, trans-epsilon-viniferin, gnetin H, suffruticosols A and B, isolated from the seeds of Paeonia lactiflora Pall. (Paeoniaceae) were determined against five different cancer cell lines, and mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100, respectively. Six stilbenes showed cytotoxic activity in a dose-dependent manner, and especially did potent cytotoxic activity against C6 (mouse glioma) cancer cell with IC50 values ranging from 8.2 to 20.5 microg/ml. trans-Resveratrol showed significant cytotoxic activity against HepG2 (liver hepatoma) and HT-29 (colon) human cancer cell lines with IC50 values of 11.8 and 25.2 g/ml, respectively. In contrast, trans-epsilon-viniferin and cis--viniferin, and gnetin H exhibited marked cytotoxic activity against Hela (cervicse) and MCF-7 (breast) human cancer cell lines with IC50 values of 20.4, 21.5, and 12.9 microg/ml, respectively. However, suffruticosol A and B had less cytotoxic effect against all cancer cells except C6. Meanwhile, six stilbenes exerted antimutagenic activity in a dose-dependent fashion. Of them, trans-resveratrol exhibited the strongest antimutagenic effect against MNNG with IC50 value of 27.0 microg/plate, while other five resveratrol oligomers also did moderate antimutagenic activity with IC50 values ranging from 31.7 to 35.2 microg/plate]

Kim YM, HT Chung, BM Choi, HJ Kim, GS Oh, HO Pae, H Oh, S Jeong, TO Kwon : 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose protects rat neuronal cells (Neuro 2A) from hydrogen peroxide-mediated cell death via the induction of heme oxygenase-1 NEUROSCIENCE LETTERS 328(2):185-189 2002 [Summary: The root of Paeonia suffruticosa ANDREWS is an important Chinese crude drug used in many traditional prescriptions. 1,2,3,4,6-Penta-O-galloyl-beta-D-glucose (PGG), a major component of this crude drug, has been shown to possess potent anti-oxidant, anti-mutagenic and anti-proliferative effects. In the present study, we examined the effect of PGG on the expression of neuronal heme oxygenase-1 (HO-1), an inducible stress protein that degrades heme to the neuroactive molecule, carbon monoxide and the anti-oxidant, biliverdin. Exposure of Neuro 2A cells to PGG (10-50 &mgr;M) resulted in a concentration- and time-dependent induction of HO-1 mRNA, and protein expressions and heme oxygenase activity. Interestingly, pretreatment of the neuronal cells with PGG resulted in enhanced cellular resistance to hydrogen peroxide. This cytoprotective effect was reversed by zinc protoporphyrin IX, an inhibitor of heme oxygenase. This study showed that PGG could protect neuronal cells from oxidative stress via the induction of HO-1 gene expression.]

Makino T, H Wakushima, T Okamoto, Y Okukubo, K Saito, Y Kano : Effects of Kangen-karyu on coagulation system and platelet aggregation in mice BIOLOGICAL & PHARMACEUTICAL BULLETIN. 25(4):523-525 2002 [Summary: Kangen-karyu (KGK) is a herbal formula created under the theory of traditional Chinese herbal medicine to invigorate the blood and dispel blood stasis. It contains 6 herbs: peony root, cnidium rhizome, safflower, cyperus rhizome, saussurea root (JP XIV), and Salvia miltiorrhiza root. The present study has been conducted to evaluate the in vivo anti-thrombotic activity of KGK using normal mice. Three consecutive days of oral administration of KGK to mice significantly extended tail-bleeding time and suppressed ex vivo platelet aggregation, while it did not extend the prothrombin time of plasma. It was revealed that the anti-thrombotic effects of KGK did not depend on the downregulation of the coagulation system, but depended in part on the inhibition of platelet aggregation. These results explain one of the pharmacological activities of KGK to invigorate the blood and dispel blood stasis.]

PapandreouV, P Magiatis, E Kalpoutzakis, AL Skaltsounis, C Harvala : Paeonicluside, a new salicylic glycoside from the Greek endemic species Paeonia clusii ZEITSCHRIFT FUR NATURFORSCHUNG C 57(3-4):235-238 2002 [Summary: A new glycoside of salicylic aldehyde, paeonicluside, was isolated from the roots of the Greek endemic species Paeonia clusii subsp. clusii and identified as alpha-L-arabinopyranosyl-(1-->6)-O-beta-D-glucopyranoside of salicylic aldehyde (1). In addition]

Papandreou V, P Magiatis, I Chinou, E Kalpoutzakis, AL Skaltsounis, A Tsarbopoulos: Volatiles with antimicrobial activity from the roots of Greek Paeonia taxa JOURNAL OF ETHNOPHARMACOLOGY 81(1):101-104 2002 [Summary:The traditional uses of the roots of Paeonia taxa are described. The volatile constituents, obtained by steam distillation of the roots of Paeonia clusii Stern subsp. clusii, Paeonia mascula L. subsp. hellenica and Paeonia parnassica, were studied by GC/MS. Salicylaldehyde, paeonol, methyl salicylate and benzoic acid were found to be the major components among the twelve constituents identified. The evaluation of the in vitro antimicrobial activity of the volatile compounds against six bacteria and three fungi is also reported.]

Qin L, Zhang SH, Li XL. [Studies on immunoregulating effect of monkshood root and peony root used singly and in combination][Article in Chinese] Zhongguo Zhong Yao Za Zhi. 2002 Jul;27(7):541-4. [OBJECTIVE: To investigate the abirritation and antiinflammation effects of Monkshood Root and Peony Root used singly and in combination, and to find the enhanced effects of the two drugs used in combination; To observe the effect of Monkshood Root and Peony Root used singly and in combination by studing the immunoregulation function in experimental animals. METHOD: The response of delayed type hypersensitivity in mice, the phagocytosis of abdominal macrophages in mice, and the production of special antibodies in mice were observed. RESULT: The two drugs used in combination could increase phagocytosic function of mononuclear macrophagocyte in hypoimmuitic model mice, and inhibit the responses of delayed type hypersensitivity in the hyperimmunitic model mice and the nonimmunosuppressive treated mice, with nosignificant effect on the production of special antibodies in mice. CONCLUSION: In accordance with the mechanism of the disorder between the anti-inflammation effect and the induce-inflammation effect on arthritis in the immune system, these data show the bidirectional effect of the two drugs used in combination on the immune responses, which may be one of the main mechanisms of treating arthralgia due to wind-dampness.] Shandong University of TCM, Jinan 250014, Shandong, China.

Raymond, Olivier, Piola, Florence , SanlavilleBoisson, Claire : Inference of reticulation in outcrossing allopolyploid taxa: Caveats, likelihood and perspectives Trends in ecology & evolution (Personal ed.) 17(1):3-6 2002 [Summary:Single- or low-copy nuclear sequences are now widely employed for phylogenetic reconstruction. In a new paper, Ferguson and Sang apply this approach to allotetraploid species of peonies Paeonia and documents the first case of natural homoploid hybrid speciation]

Rieck, Irmtraud & Friedrich Hertle 2002 Strauchpfingstrosen, Eugen Ulmer Verlag Stuttgart, ISBN 3-8001-3657-0, 168 Seiten, 150 Farbfotos.

Rivière, Jean-Luc : Pivoines : comment les choisir et les cultiver facilement, ISBN 2-84138-152-8, 2002, Ulmer

SanchezLafuenteAlfonso M : Floral variation in the generalist perennial herb Paeonia broteroi (Paeoniaceae): Differences between regions with different pollinators and herbivores AMERICAN JOURNAL OF BOTANY 89(8):1260-1269 2002

Shen Bao An & Liu Chang Geng: 2002: Peony cultivation technology for medicinal purposes Shen Bao An, (Anhui Province Wuhu institute for drug control 241,001), Liu Chang Geng (South Anhui Province Ling Xian drug company 242,400) published online under: , translation available here.

Wang H & van StadenJ Seedling establishment characteristics of Paeonia ostii var. lishizhenii (pp. 382 - 385)  [H Wang, Present address: College of Plant Sciences, Beijing Forestry University, Beijing, 100083, China, e-mail: J van Staden, Research Centre for Plant Growth and Development, School of Botany and Zoology, University of Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa [Abstract The viability of Paeonia ostii var. lishizhenii seed used in this investigation was around 85% when tested under optimum conditions of tissue culture. Seedling establishment embodied radicle protrusion and breaking of epicotyl dormancy. The seed coat, an endosperm extract, and GA3 significantly influenced embryo emergence. The seed coat is not an appreciable barrier to water uptake but exhibited a degree of mechanical resistance. Both the coat and endosperm extract inhibited germination. Removal of the radicle end of the testa and soaking in GA3 (100–200mgl-1) promoted radicle growth at 15ºC. Epicotyl dormancy was broken by soaking seeds in GA3 or maintaining excised embryos on Woody Plant Medium containing 1mgl-1 GA3. Chilling at 5ºC for 30 days was required to break epicotyl dormancy of emerged embryos. The seed structures surrounding the embryos impose mechanical and chemical restraints on germination. The embryo itself appears to be lacking growth promoters as exogenous GA3 promoted epicotyl growth. South African Journal of Botany 2002, 68: 382–385]

Yuan Tao & Wang Lianying (2002) Discussion on the origination of Chinese tree peony cultivars according to pollen grain morphology. Journal of Beijing Forestry University 24(1): 5 – 11.

Zhang HY, Qin L, Xue L, Zhang SH. [Studies on the anti-inflammation effect of the TCM prescription of a combination of monkshood root with peony root] [Article in Chinese] Zhongguo Zhong Yao Za Zhi. 2002 Jun;27(6):449-52. [OBJECTIVE: To make a comparison between the single and combined use of Monkshood Root and Peony Root to observe the anti-inflammation effect in the experimental animals. METHOD: The experimental inflammatory models were adopted, i.e. adjuvant-induced polyarthritis carrageenan-induced or formaldehyde-induced rat paw edema, and cotton pellet-induced granuloma formation in rats xylene-induced mouse ear edema, exudation of abdominal blood capillaries of mice, etc. RESULT: The anti-inflammafion effect of Monkshood Root was weaker than that of Peony Root or Peony Root combined with Monkshood Root. It was found that anti-inflammation effect with the drug-cooperation was enhanced more significantly in the formaldehyde-induced or adjuvant-induceed arthritis models than in the carrageenan-induced rat paw edema and other inflammatory models either in the large dosage of 1:1 proportion or in the small dosage of 1:2 proportion. CONCLUSION: The drug-cooperation has a good selective and synergic effect on anti-inflammation.] Shandong University of TCM, Jinan 250014, Shandong, China

Zhou HT, Hu SL, Guo BL, Feng XF, Yan YN, Li JS. [A study on genetic variation between wild and cultivated populations of Paeonia lactiflora Pall.] [Article in Chinese] Yao Xue Xue Bao. (ACTA PHARMACEUTICA SINICA) 2002 May;37(5):383-8. [Abstract: AIM: To discuss the genetic differentiation between wild and cultivated populations of Paeonia lactiflora Pall., and to find the reason for forming the genuineness of Radix Paeoniae rubra (Chishao) and Radix Paeoniae alba (Baishao). METHODS: Forty three representative samples of P. lactiflora from 11 localities were analyzed by RAPD method with 21 random primers. According to RAPD results, the genetic diversity and genetic differentiation of P. lactiflora were detected by the percentage of polymorphic sites (PPB), the coefficient of gene differentiation (GST) and analysis of molecular variance (AMOVA). RESULTS: (1) At species level, the PPB of P. lactiflora was 85.26%, the Nei's gene diversity (Ht) was 0.166. The PPB in wild population (WP) was 77.61%, which was more than that (54.96%) in cultivated population for medicine (MP), and that (61.76%) in cultivated population for ornament (OP). (2) AMOVA showed that 29.50% of the genetic diversity resulted from differentiation among populations. Pairwise Phist distance (0.3632) between WP and MP was furthest, while that (0.0973) between MP and OP was closest, indicating population differentiation was significant (P < 0.001). (3) In general, cluster analysis revealed that the samples of P. lactiflora were divided in wild and cultivated groups (except for 39). In WP, individuals of Duolun were separated from those of other localities. In MP, the clusters of samples corresponded well with their own habitats. CONCLUSION: In addition to environmental factor, genetic differentiation should be the main cause for the genuineness of "Chishao" and "Baishao". Because of over collection and worse habitat, P. lactiflora in Duolun, whose root is the famous Chinese Geo-herbal--"Duolun Chishao", is progresively rare. So, it should become the endangered germplasm resource to protect.] Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine, Beijing 100700, China.

Carsten Burkhardt's Web Project Paeonia - The Peony Library

ano_finnland7 index 0602 boreas2

Paeonia-Literatur 2002