2019

Tu J, Guo Y, Hong W, Fang Y, Han D, Zhang P, Wang X, Körner H, Wei W. The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6'-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases. Front Pharmacol. 2019 Feb 5;10:57. doi: 10.3389/fphar.2019.00057. eCollection 2019. Review. PMID: 30804784

Zhang F, Qu J, Thakur K, Zhang JG, Mocan A, Wei ZJ. Purification and identification of an antioxidative peptide from peony (Paeonia suffruticosa Andr.) seed dreg. Food Chem. 2019 Jul 1;285:266-274. doi: 10.1016/j.foodchem.2019.01.168. Epub 2019 Feb 2. PMID: 30797344

Chen CM, Chen WL, Hung CT, Lin TH, Lee MC, Chen IC, Lin CH, Chao CY, Wu YR, Chang KH, Hsieh-Li HM, Lee-Chen GJ. Shaoyao Gancao Tang (SG-Tang), a formulated Chinese medicine, reduces aggregation and exerts neuroprotection in spinocerebellar ataxia type 17 (SCA17) cell and mouse models. Aging (Albany NY). 2019 Feb 13;11(3):986-1007. doi: 10.18632/aging.101804. PMID: 30760647 [Free Article]

Liu X, Zheng X, Du G, Li Z, Qin X. Brain metabonomics study of the antidepressant-like effect of Xiaoyaosan on the CUMS-depression rats by 1H NMR analysis. J Ethnopharmacol. 2019 Jan 29;235:141-154. doi: 10.1016/j.jep.2019.01.018. [Epub ahead of print] PMID: 30708033

Zhao D, Tang Y, Xia X, Sun J, Meng J, Shang J, Tao J. Integration of Transcriptome, Proteome, and Metabolome Provides Insights into How Calcium Enhances the Mechanical Strength of Herbaceous Peony Inflorescence Stems. Cells. 2019 Jan 30;8(2). pii: E102. doi: 10.3390/cells8020102. PMID: 30704139 [Free Article]

Zhao D, Xia X, Su J, Wei M, Wu Y, Tao J. Overexpression of herbaceous peony HSP70 confers high temperature tolerance. BMC Genomics. 2019 Jan 21;20(1):70. doi: 10.1186/s12864-019-5448-0. PMID: 30665351 [Free PMC Article]

Zhao DQ, Li TT, Hao ZJ, Cheng ML, Tao J. Exogenous trehalose confers high temperature stress tolerance to herbaceous peony by enhancing antioxidant systems, activating photosynthesis, and protecting cell structure. Cell Stress Chaperones. 2019 Jan;24(1):247-257. doi: 10.1007/s12192-018-00961-1. Epub 2019 Jan 10. PMID: 30632065



Jiang J, Yu Y, Wang L, Li J, Ling J, Li Y, Duan G. Enzyme immobilized on polyamidoamine-coated magnetic microspheres for α-glucosidase inhibitors screening from Radix Paeoniae Rubra extracts accompanied with molecular modeling. Talanta. 2019 Apr 1;195:127-136. doi: 10.1016/j.talanta.2018.11.009. Epub 2018 Nov 6. PMID: 30625522

Liu X, Chen K, Zhuang Y, Huang Y, Sui Y, Zhang Y, Lv L, Zhang G. Paeoniflorin improves pressure overload-induced cardiac remodeling by modulating the MAPK signaling pathway in spontaneously hypertensive rats. Biomed Pharmacother. 2019 Jan 3;111:695-704. doi: 10.1016/j.biopha.2018.12.090. [Epub ahead of print] PMID: 30611994 [Free Article]



2018

Wang B, Dai W, Shi L, Teng H, Li X, Wang J, Geng W. Neuroprotection by Paeoniflorin against Nuclear Factor Kappa B-Induced Neuroinflammation on Spinal Cord Injury. Biomed Res Int. 2018 Dec 2;2018:9865403. doi: 10.1155/2018/9865403. eCollection 2018. PMID: 30627586 [Free PMC Article]

Kim KJ, Ahn HJ, Namgung U, Cho CS. Bogijetong Decoction and Its Selected Formulation Are Involved in Alleviating Neuropathic Pain in a Rat Model of Chronic Constrictive Injury. Evid Based Complement Alternat Med. 2018 Dec 5;2018:2050636. doi: 10.1155/2018/2050636. eCollection 2018. PMID: 30622591 [Free PMC Article]

Wang X, Guan YX, Ding DL, Wei SQ, Liu H, Zheng Y. [Research on rhizospheric and endophytic actinomycetes in medicinal tree peony(Paeoniasuffruticosa) from five producing regions]. Zhongguo Zhong Yao Za Zhi. 2018 Nov;43(22):4419-4426. doi: 10.19540/j.cnki.cjcmm.20180821.002. Chinese. PMID:30593233

Zhang Q, Yu R, Sun D, Rahman MM, Xie L, Hu J, He L, Kilaru A, Niu L, Zhang Y. Comparative Transcriptome Analysis Reveals an Efficient Mechanism of α-Linolenic Acid in Tree Peony Seeds. Int J Mol Sci. 2018 Dec 24;20(1). pii: E65. doi: 10.3390/ijms20010065. PMID:30586917 [Free PMC Article]

Xue J, Li T, Wang S, Xue Y, Liu X, Zhang X. Defoliation and gibberellin synergistically induce tree peony flowering with non-structural carbohydrates as intermedia. J Plant Physiol. 2019 Feb;233:31-41. doi: 10.1016/j.jplph.2018.12.004. Epub 2018 Dec 12. PMID:30580057

Yu F, Xu N, Zhao B, Ren X, Zhang F. Successful treatment of isolated oral lichen planus on lower lip with traditional Chinese medicine and topical wet dressing: A case report. Medicine (Baltimore). 2018 Dec;97(50):e13630. doi: 10.1097/MD.0000000000013630. PMID:30558050 [Free PMC Article]

Wang S, Peng MC, Chen X, Yu Liu C, Chen Y, Dan Liu X, Bao Zhou R. Molecular cloning and spatiotemporal expression of APETALA1-like gene in Lonicera macranthoides. J Genet. 2018 Dec;97(5):1281-1288. PMID: 30555076 [Free Article]

Yang RX, Zhang SW, Xue D, Xuan JH, Zhang YB, Peng BB. Culturable Endophytes Diversity Isolated from Paeonia ostii and the Genetic Basis for Their Bioactivity. Pol J Microbiol. 2018;67(4):441-454. doi: 10.21307/pjm-2018-052.

Lei G, Li J, Zheng T, Yao J, Chen J, Duan L. Comparative Chemical Profiles of Essential Oils and Hydrolate Extracts from Fresh Flowers of Eight Paeonia suffruticosa Andr. Cultivars from Central China. Molecules. 2018 Dec 10;23(12). pii: E3268. doi: 10.3390/molecules23123268. [Free PMC Article]

Ma L, Jiao K, Luo L, Xiang J, Fan J, Zhang X, Yi J, Zhu W. Characterization and macrophage immunomodulatory activity of two polysaccharides from the flowers of Paeonia suffruticosa Andr. Int J Biol Macromol. 2019 Mar 1;124:955-962. doi: 10.1016/j.ijbiomac.2018.12.035. Epub 2018 Dec 4.

Chen IC, Lin TH, Hsieh YH, Chao CY, Wu YR, Chang KH, Lee MC, Lee-Chen GJ, Chen CM. Formulated Chinese Medicine Shaoyao Gancao Tang Reduces Tau Aggregation and Exerts Neuroprotection through Anti-Oxidation and Anti-Inflammation. Oxid Med Cell Longev. 2018 Oct 28;2018:9595741. doi: 10.1155/2018/9595741. eCollection 2018. [Free PMC Article]

Gu Z, Zhu J, Hao Q, Yuan YW, Duan Y, Men S, Wang Q, Hou Q, An Liu Z, Shu Q, Wang L. A novel R2R3-MYB transcription factor contributes to petal blotch formation by regulating organ-specific expression of PsCHS in tree peony (Paeonia suffruticosa). Plant Cell Physiol. 2018 Nov 29. doi: 10.1093/pcp/pcy232. [Epub ahead of print]

Sut S, Zengin G, Dall'Acqua S, Gazdová M, Šmejkal K, Bulut G, Dogan A, Haznedaroglu MZ, Aumeeruddy MZ, Maggi F, Mahomoodally MF. Paeonia arietina and Paeonia kesrounansis bioactive constituents: NMR, LC-DAD-MS fingerprinting and in vitro assays. J Pharm Biomed Anal. 2019 Feb 20;165:1-11. doi: 10.1016/j.jpba.2018.11.040. Epub 2018 Nov 19.

Rabie ABM, Ho JK.The mechanism of action of Lipiburn on fat metabolism. Front Biosci (Landmark Ed). 2019 Jan 1;24:427-434.

Mahdavi Fikejvar E, Rezadoost H, Zakizadeh H, Mozaffarian V. A comparative study on the essential oil composition and antibacterial activities of different organs of wild growing Paeonia daurica subsp. tomentosa from Iran. Nat Prod Res. 2018 Nov 16:1-4. doi: 10.1080/14786419.2018.1516665. [Epub ahead of print]

Cheng X, Wei Z, Pu S, Xiang M, Yan A, Zhang Y, Wang X. Diversity of endophytic fungi of Paeonia lactiflora Pallas and screening for fungal paeoniflorin producers. FEMS Microbiol Lett. 2018 Dec 1;365(24). doi: 10.1093/femsle/fny263.

Zhou JX, Wink M. Reversal of Multidrug Resistance in Human Colon Cancer and Human Leukemia Cells by Three Plant Extracts and Their Major Secondary Metabolites. Medicines (Basel). 2018 Nov 13;5(4). [Free PMC Article] pii: E123. doi: 10.3390/medicines5040123.

Deng RX, Yang X, Wang YX, Du MZ, Hao XT, Liu P. Optimization of Ultrasound-Assisted Extraction of Monoterpene Glycoside from Oil Peony Seed Cake. J Food Sci. 2018 Dec;83(12):2943-2953. doi: 10.1111/1750-3841.14378. Epub 2018 Nov 11.

Abd El-Aal NF, Abdelbary EH. Paeoniflorin in experimental BALB/c mansoniasis: A novel anti-angiogenic therapy. Exp Parasitol. 2019 Feb;197:85-92. doi: 10.1016/j.exppara.2018.11.002. Epub 2018 Nov 8.

Wu Y, Tang Y, Jiang Y, Zhao D, Shang J, Tao J. Combination of transcriptome sequencing and iTRAQ proteome reveals the molecular mechanisms determining petal shape in herbaceous peony (Paeonia lactiflora Pall.). Biosci Rep. 2018 Dec 11;38(6). pii: BSR20181485. doi: 10.1042/BSR20181485. Print 2018 Dec 21.[Free PMC Article]

Ibrar M, Khan MA, Abdullah, Nisar M, Khan M. Evaluation of Paeonia emodi for its cardioprotective potentials: An investigative study towards possible mechanism. J Ethnopharmacol. 2019 Mar 1;231:57-65. doi: 10.1016/j.jep.2018.10.041. Epub 2018 Nov 2.

Li XY, Xu JD, Zhou SS, Kong M, Xu YY, Zou YT, Tang Y, Zhou L, Xu MZ, Xu J, Li SL. Time segment scanning-based quasi-multiple reaction monitoring mode by ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry for quantitative determination of herbal medicines: Moutan Cortex, a case study. J Chromatogr A. 2018 Dec 21;1581-1582:33-42. doi: 10.1016/j.chroma.2018.10.047. Epub 2018 Oct 28.

Guo L, Guo D, Yin W, Hou X. Tolerance strategies revealed in tree peony (Paeonia suffruticosa; Paeoniaceae) ecotypes differentially adapted to desiccation. Appl Plant Sci. 2018 Oct 25;6(10):e01191. doi: 10.1002/aps3.1191. eCollection 2018 Oct. [Free PMC Article]

Wang JT, Zhang PL, Liu JS, Wang GK, Xu FQ, Chen L, Yu Y, Wang G. Aspergilates A to E, second metabolites from Aspergillus sp. isolated from Paeonia ostii. Fitoterapia. 2018 Nov;131:204-208. doi: 10.1016/j.fitote.2018.10.027. Epub 2018 Oct 29.

Zhao X, Qiao D, Hou M. [Effect of Acupuncture Combined with Gavage of Rule Granule on Serum Prolactin, Estradiol and Progestone Contents and Their Receptor Expression in Breast in Mammary Gland Hyperplasia Rats]. Zhen Ci Yan Jiu. 2018 Oct 25;43(10):645-50. doi: 10.13702/j.1000-0607.170117. Chinese.

Rozalia M, Konstantina S, Panagiotis P, Dimitra B, Emmanuel M, Nektarios A. Efficient identification of Acetylcholinesterase and Hyaluronidase inhibitors from Paeoniaparnassica extracts through a HeteroCovariance Approach. J Ethnopharmacol. 2018 Oct 15. pii: S0378-8741(18)32201-3. doi: 10.1016/j.jep.2018.10.008. [Epub ahead of print]

Xue J, Li T, Wang S, Xue Y, Hu F, Zhang X. Elucidation of the mechanism of reflowering in tree peony (Paeonia suffruticosa) 'Zi Luo Lan' by defoliation and gibberellic acid application. Plant Physiol Biochem. 2018 Nov;132:571-578. doi: 10.1016/j.plaphy.2018.10.004. Epub 2018 Oct 10.

Yin YC, Zhang XD, Gao ZQ, Hu T, Liu Y. The Research Progress of Chalcone Isomerase (CHI) in Plants. Mol Biotechnol. 2019 Jan;61(1):32-52. doi: 10.1007/s12033-018-0130-3. Review.

Anatomical and biochemical analyses reveal the mechanism of double-color formation in Paeoniasuffruticosa 'Shima Nishiki'.
Zhang X, Zhao M, Guo J, Zhao L, Xu Z.
3 Biotech. 2018 Oct;8(10):420. doi: 10.1007/s13205-018-1459-9. Epub 2018 Sep 26.
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Paeonia lactiflora Pall. regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats.
Ma X, Wen JX, Gao SJ, He X, Li PY, Yang YX, Wei SZ, Zhao YL, Xiao XH.
J Pharm Pharmacol. 2018 Dec;70(12):1675-1687. doi: 10.1111/jphp.13008. Epub 2018 Sep 14.
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A review of the seed biology of Paeonia species (Paeoniaceae), with particular reference to dormancy and germination.
Zhang K, Yao L, Zhang Y, Baskin JM, Baskin CC, Xiong Z, Tao J.
Planta. 2019 Feb;249(2):291-303. doi: 10.1007/s00425-018-3017-4. Epub 2018 Oct 1. Review.
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Evaluation of Paeonia emodi and its gold nanoparticles for cardioprotective and antihyperlipidemic potentials.
Ibrar M, Khan MA, Abdullah, Imran M.
J Photochem Photobiol B. 2018 Dec;189:5-13. doi: 10.1016/j.jphotobiol.2018.09.018. Epub 2018 Sep 22.
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Screening and Whole-Genome Sequencing of Two Streptomyces Species from the Rhizosphere Soil of Peony Reveal Their Characteristics as Plant Growth-Promoting Rhizobacteria.
Wang C, Wang Y, Ma J, Hou Q, Liu K, Ding Y, Du B.
Biomed Res Int. 2018 Sep 5;2018:2419686. doi: 10.1155/2018/2419686. eCollection 2018.
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Paenibacillus paeoniae sp. nov., a novel endophytic bacterium isolated from leaf of Paeonialactiflora Pall.
Yan XR, Tuo L.
Int J Syst Evol Microbiol. 2018 Nov;68(11):3606-3610. doi: 10.1099/ijsem.0.003042. Epub 2018 Sep 25.
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Pharmacokinetic-pharmacodynamic modeling to study the anti-dysmenorrhea effect of Guizhi Fuling capsule on primary dysmenorrhea rats.
Cheng Y, Chu Y, Su X, Zhang K, Zhang Y, Wang Z, Xiao W, Zhao L, Chen X.
Phytomedicine. 2018 Sep 15;48:141-151. doi: 10.1016/j.phymed.2018.04.041. Epub 2018 Apr 17.
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Paeoniflorin extract reverses dexamethasone-induced testosterone over-secretion through downregulation of cytochrome P450 17A1 expression in primary murine theca cells.
Ong M, Cheng J, Jin X, Lao W, Johnson M, Tan Y, Qu X.
J Ethnopharmacol. 2019 Jan 30;229:97-103. doi: 10.1016/j.jep.2018.09.006. Epub 2018 Sep 5.
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Jin Gui Shen Qi Wan, a traditional Chinese medicine, alleviated allergic airway hypersensitivity and inflammatory cell infiltration in a chronic asthma mouse model.
Kao ST, Wang SD, Lin CC, Lin LJ.
J Ethnopharmacol. 2018 Dec 5;227:181-190. doi: 10.1016/j.jep.2018.08.028. Epub 2018 Aug 30.
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Diversity and communities of culturable endophytic fungi from different tree peonies (geoherbs and non-geoherbs), and their biosynthetic potential analysis.
Yang G, Li P, Meng L, Xv K, Dong F, Qiu Y, He L, Lin L.
Braz J Microbiol. 2018 Nov;49 Suppl 1:47-58. doi: 10.1016/j.bjm.2018.06.006. Epub 2018 Aug 17.
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Advancement in the chemical analysis of Paeoniae Radix (Shaoyao).
Yan B, Shen M, Fang J, Wei D, Qin L.
J Pharm Biomed Anal. 2018 Oct 25;160:276-288. doi: 10.1016/j.jpba.2018.08.009. Epub 2018 Aug 7. Review.
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Behavior of pesticides and their metabolites in traditional Chinese medicine Paeoniae Radix Alba during processing and associated health risk.
Xiao JJ, Duan JS, Xu X, Li SN, Wang F, Fang QK, Liao M, Cao HQ.
J Pharm Biomed Anal. 2018 Nov 30;161:20-27. doi: 10.1016/j.jpba.2018.08.029. Epub 2018 Aug 15.
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Pharmacokinetics and Brain Distribution of the Active Components of DA-9805, Saikosaponin A, Paeonol, and Imperatorin in Rats.
Kwon MH, Jeong JS, Ryu J, Cho YW, Kang HE.
Pharmaceutics. 2018 Aug 20;10(3). pii: E133. doi: 10.3390/pharmaceutics10030133.
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Paeoniflorin attenuates atRAL-induced oxidative stress, mitochondrial dysfunction and endoplasmic reticulum stress in retinal pigment epithelial cells via triggering Ca2+/CaMKII-dependent activation of AMPK.
Zhu X, Wang K, Zhou F, Zhu L.
Arch Pharm Res. 2018 Oct;41(10):1009-1018. doi: 10.1007/s12272-018-1059-6. Epub 2018 Aug 16.
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[Chemical constituents from water-soluble extract of dry roots of Paeonia lactiflora].
Li R, Li YC, Wu YZ, Wang LY, Qiu BL, Zhang JF, Lin S.
Zhongguo Zhong Yao Za Zhi. 2018 Jul;43(14):2956-2963. doi: 10.19540/j.cnki.cjcmm.20170512.010. Chinese.
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[Morphological, microscopic, multiple-component assay and fingerprinting based systematic research on quality evaluation of Moutan Cortex(Paeonia suffruticosa)].
Wang ZQ, Chen Y, Liu SS, Li HX, Li WW, Dong L, He CN, Chen FH, Xiao PG.
Zhongguo Zhong Yao Za Zhi. 2018 Jul;43(14):2899-2907. doi: 10.19540/j.cnki.cjcmm.20180510.002. Chinese.
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Aqueous extracts of Paeonia suffruticosa modulates mitochondrial proteostasis by reactive oxygen species-induced endoplasmic reticulum stress in pancreatic cancer cells.
Liu YH, Weng YP, Tsai HY, Chen CJ, Lee DY, Hsieh CL, Wu YC, Lin JY.
Phytomedicine. 2018 Jul 15;46:184-192. doi: 10.1016/j.phymed.2018.03.037. Epub 2018 Mar 27.
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Characterization of the glycerol-3-phosphate acyltransferase gene and its real-time expression under cold stress in Paeonia lactiflora Pall.
Li X, Liu P, Yang P, Fan C, Sun X.
PLoS One. 2018 Aug 10;13(8):e0202168. doi: 10.1371/journal.pone.0202168. eCollection 2018.
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Moutan Cortex Radicis inhibits the nigrostriatal damage in a 6-OHDA-induced Parkinson's disease model.
Choi YG, Hong YM, Kim LH, Yeo S, Lim S.
Chin J Nat Med. 2018 Jul;16(7):490-498. doi: 10.1016/S1875-5364(18)30084-0.
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Fatty acid desaturase 3 (PsFAD3) from Paeonia suffruticosa reveals high α-linolenic acid accumulation.
Yin DD, Xu WZ, Shu QY, Li SS, Wu Q, Feng CY, Gu ZY, Wang LS.
Plant Sci. 2018 Sep;274:212-222. doi: 10.1016/j.plantsci.2018.05.027. Epub 2018 May 29.
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Paeoniflorin inhibits mast cell-mediated allergic inflammation in allergic rhinitis.
Wang G, Cheng N.
J Cell Biochem. 2018 Nov;119(10):8636-8642. doi: 10.1002/jcb.27135. Epub 2018 Aug 4.
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The protective effects of total paeony glycoside on ischemia/reperfusion injury in H9C2 cells via inhibition of the PI3K/Akt signaling pathway.
Shen P, Chen J, Pan M.
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Age-associated methylation change of CHI promoter in herbaceous peony (Paeonia lactiflora Pall).
Wu Y, Liu L, Zhao D, Tao J.
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Paeoniflorin protects against liver ischemia/reperfusion injury in mice via inhibiting HMGB1-TLR4 signaling pathway.
Xie T, Li K, Gong X, Jiang R, Huang W, Chen X, Tie H, Zhou Q, Wu S, Wan J, Wang B.
Phytother Res. 2018 Nov;32(11):2247-2255. doi: 10.1002/ptr.6161. Epub 2018 Jul 26.
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Simultaneous determination of five bioactive components of Gancao in rat plasma by UHPLC-MS/MS and its application to comparative pharmacokinetic study of incompatible herb pair Gansui-Gancao and Gansuibanxia Decoction.
Cui Y, Liu T, Zhang Y, Wang R, Liu X, Zhang Q, Yu P, Zhao Y, Yu Z.
J Pharm Biomed Anal. 2018 Sep 10;159:318-325. doi: 10.1016/j.jpba.2018.07.014. Epub 2018 Jul 14.
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Chemical markers for quality control of bran-fried sulfur-fumigated Paeoniae Radix Alba.
Xu YY, Long F, Zhang YQ, Xu JD, Kong M, Li SL.
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Peony.
Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-.
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Inhibitory effects of TGP on KGF induced hyperproliferation of HaCaT cells via suppression of the p38 MAPK/NF κB p65 pathway.
Pang W, Qi X, Cao C, Zhang S.
Mol Med Rep. 2018 Aug;18(2):2207-2215. doi: 10.3892/mmr.2018.9177. Epub 2018 Jun 15.
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Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats.
Long Y, Li S, Qin J, Xie L, Gan L, Jie F, Wu Y, Li Y, Du Q.
Biomed Pharmacother. 2018 Sep;105:781-788. doi: 10.1016/j.biopha.2018.06.011. Epub 2018 Jun 15.
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Oil biosynthesis and transcriptome profiles in developing endosperm and oil characteristic analyses in Paeonia ostii var. lishizhenii.
Xiu Y, Wu G, Tang W, Peng Z, Bu X, Chao L, Yin X, Xiong J, Zhang H, Zhao X, Ding J, Ma L, Wang H, van Staden J.
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Paeoniflorin Antagonizes TNF-α-Induced L929 Fibroblastoma Cells Apoptosis by Inhibiting NF-κBp65 Activation.
Lai X, Wei J, Ding X.
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Paeonol attenuates acute lung injury by inhibiting HMGB1 in lipopolysaccharide-induced shock rats.
Liu X, Xu Q, Mei L, Lei H, Wen Q, Miao J, Huang H, Chen D, Du S, Zhang S, Zhou J, Deng R, Li Y, Li C, Li H.
Int Immunopharmacol. 2018 Aug;61:169-177. doi: 10.1016/j.intimp.2018.05.032. Epub 2018 Jun 5.
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Efficacy and safety of Xuebijing injection (a Chinese patent) for sepsis: A meta-analysis of randomized controlled trials.
Li C, Wang P, Zhang L, Li M, Lei X, Liu S, Feng Z, Yao Y, Chang B, Liu B, Shang H.
J Ethnopharmacol. 2018 Oct 5;224:512-521. doi: 10.1016/j.jep.2018.05.043. Epub 2018 Jun 1. Review.
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Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus.
Zhao Z, Han Y, Zhang Z, Li W, Ji X, Liu X, Jin J, Xu S, Cui H, Cheng Z, Wang Q, Wang X, Guo X, Wang Y, Liu H.
Biomed Pharmacother. 2018 Sep;105:151-158. doi: 10.1016/j.biopha.2018.05.076. Epub 2018 May 29.
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The Antitumor Mechanism of Paeonol on CXCL4/CXCR3-B Signals in Breast Cancer Through Induction of Tumor Cell Apoptosis.
Saahene RO, Wang J, Wang ML, Agbo E, Pang D.
Cancer Biother Radiopharm. 2018 Aug;33(6):233-240. doi: 10.1089/cbr.2018.2450. Epub 2018 May 30.
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Phytochemical analysis and mode of action against Candida glabrata of Paeonia emodi extracts.
Sharma A, Singh S, Tewari R, Bhatt VP, Sharma J, Maurya IK.
J Mycol Med. 2018 Sep;28(3):443-451. doi: 10.1016/j.mycmed.2018.04.008. Epub 2018 May 24.
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[Screening and phosphate-solubilizing characteristics of phosphate-solubilizing actinomycetes in rhizosphere of tree peony.]
Xue D, Huang XD, Yang RX, Wang ZH.
Ying Yong Sheng Tai Xue Bao. 2018 May;29(5):1645-1652. doi: 10.13287/j.1001-9332.201805.035. Chinese.
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Effects of different chemical modifications on the antibacterial activities of polysaccharides sequentially extracted from peony seed dreg.
Li XL, Thakur K, Zhang YY, Tu XF, Zhang YS, Zhu DY, Zhang JG, Wei ZJ.
Int J Biol Macromol. 2018 Sep;116:664-675. doi: 10.1016/j.ijbiomac.2018.05.082. Epub 2018 May 15.
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Melatonin and Expression of Tryptophan Decarboxylase Gene (TDC) in Herbaceous Peony (Paeonia lactiflora Pall.) Flowers.
Zhao D, Wang R, Liu D, Wu Y, Sun J, Tao J.
Molecules. 2018 May 12;23(5). pii: E1164. doi: 10.3390/molecules23051164.
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[Characterization of sediment of water extract of Guizhi decoction and its effect on relevant compound (fractions) in decoction].
Yuan HJ, Li W, Jin JM, Jia XB, Zhou T, Wang H, Sun E, Ni HY.
Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(8):1633-1641. doi: 10.19540/j.cnki.cjcmm.20180117.004. Chinese.
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Chemical profiling in Moutan Cortex after sulfuring and desulfuring processes reveals further insights into the quality control of TCMs by nontargeted metabolomic analysis.
Zhan ZL, Deng AP, Kang LP, Tang JF, Nan TG, Chen T, He YL, Guo LP, Huang LQ.
J Pharm Biomed Anal. 2018 Jul 15;156:340-348. doi: 10.1016/j.jpba.2018.04.045. Epub 2018 May 1.
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Paeonol extracted from Paeonia suffruticosa Andr. ameliorated UVB-induced skin photoaging via DLD/Nrf2/ARE and MAPK/AP-1 pathway.
Sun Z, Du J, Hwang E, Yi TH.
Phytother Res. 2018 Sep;32(9):1741-1749. doi: 10.1002/ptr.6100. Epub 2018 May 10.
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Herbal Medicine for Oligomenorrhea and Amenorrhea: A Systematic Review of Ancient and Conventional Medicine.
Moini Jazani A, Hamdi K, Tansaz M, Nazemiyeh H, Sadeghi Bazargani H, Fazljou SMB, Nasimi Doost Azgomi R.
Biomed Res Int. 2018 Mar 18;2018:3052768. doi: 10.1155/2018/3052768. eCollection 2018. Review.
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Structures and Biological Evaluation of Monoterpenoid Glycosides from the Roots of Paeonialactiflora.
Li R, Zhang JF, Wu YZ, Li YC, Xia GY, Wang LY, Qiu BL, Ma M, Lin S.
J Nat Prod. 2018 May 25;81(5):1252-1259. doi: 10.1021/acs.jnatprod.8b00087. Epub 2018 May 9.
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Paeoniflorin inhibits glioblastoma growth in vivo and in vitro: a role for the Triad3A-dependent ubiquitin proteasome pathway in TLR4 degradation.
Wang Z, Yu G, Liu Z, Zhu J, Chen C, Liu RE, Xu R.
Cancer Manag Res. 2018 Apr 27;10:887-897. doi: 10.2147/CMAR.S160292. eCollection 2018.
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Identification of microRNAs and long non-coding RNAs involved in fatty acid biosynthesis in tree peony seeds.
Yin DD, Li SS, Shu QY, Gu ZY, Wu Q, Feng CY, Xu WZ, Wang LS.
Gene. 2018 Aug 5;666:72-82. doi: 10.1016/j.gene.2018.05.011. Epub 2018 May 5.
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Paeonol Reduces the Nucleocytoplasmic Transportation of HMGB1 by Upregulating HDAC3 in LPS-Induced RAW264.7 Cells.
Xu Q, Liu X, Mei L, Wen Q, Chen J, Miao J, Lei H, Huang H, Chen D, Du S, Liu A, Zhang S, Zhou J, Deng R, Li Y, Li C, Li H.
Inflammation. 2018 May 7. doi: 10.1007/s10753-018-0800-0. [Epub ahead of print]
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[Exploration on mechanism of anti-influenza virus activity of genus Paeonia based on network pharmacology].
Cai YQ, Bao YT, Wang HJ, Ren XD, Huang LF, He J, Liu TT, Zeng R.
Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(7):1476-1483. doi: 10.19540/j.cnki.cjcmm.20180123.002. Chinese.
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[Analysis on "component-target-pathway" of Paeonia lactiflora in treating cardiac diseases based on data mining].
Liu Y, Zhang FB, Tang SH, Wang P, Li S, Su J, Zhou RR, Zhang JQ, Sun HF.
Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(7):1310-1316. doi: 10.19540/j.cnki.cjcmm.2018.0053. Chinese.
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Maxent modeling for predicting the potential geographical distribution of two peony species under climate change.
Zhang K, Yao L, Meng J, Tao J.
Sci Total Environ. 2018 Sep 1;634:1326-1334. doi: 10.1016/j.scitotenv.2018.04.112. Epub 2018 Apr 18.
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Paeoniflorin improves cardiac function and decreases adverse postinfarction left ventricular remodeling in a rat model of acute myocardial infarction.
Chen H, Dong Y, He X, Li J, Wang J.
Drug Des Devel Ther. 2018 Apr 12;12:823-836. doi: 10.2147/DDDT.S163405. eCollection 2018.
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Radix Paeoniae Rubra stimulates osteoclast differentiation by activation of the NF-κB and mitogen-activated protein kinase pathways.
Tzeng HE, Tsai CH, Ho TY, Hsieh CT, Chou SC, Lee YJ, Tsay GJ, Huang PH, Wu YY.
BMC Complement Altern Med. 2018 Apr 23;18(1):132. doi: 10.1186/s12906-018-2196-7.
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Rapid characterization of chemical markers for discrimination of Moutan Cortex and its processed products by direct injection-based mass spectrometry profiling and metabolomic method.
Li CR, Li MN, Yang H, Li P, Gao W.
Phytomedicine. 2018 Jun 1;45:76-83. doi: 10.1016/j.phymed.2018.04.003. Epub 2018 Apr 3.
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Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components.
Li S, Chu Y, Zhang R, Sun L, Chen X.
Nutrients. 2018 Apr 20;10(4). pii: E514. doi: 10.3390/nu10040514.
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Cloning, Characterization, and Expression Analysis of Three FAD8 Genes Encoding a Fatty Acid Desaturase from Seeds of Paeonia ostii.
Sun J, Chen M, Zhu M, Jiang Y, Meng J, Zhao D, Tao J.
Molecules. 2018 Apr 17;23(4). pii: E929. doi: 10.3390/molecules23040929.
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Inhibition of Rabies Virus by 1,2,3,4,6-Penta-O-galloyl-β-d-Glucose Involves mTOR-Dependent Autophagy.
Tu Z, Gong W, Zhang Y, Feng Y, Liu Y, Tu C.
Viruses. 2018 Apr 17;10(4). pii: E201. doi: 10.3390/v10040201.
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Impact of different post-harvest processing methods on the chemical compositions of peony root.
Zhu S, Shirakawa A, Shi Y, Yu X, Tamura T, Shibahara N, Yoshimatsu K, Komatsu K.
J Nat Med. 2018 Jun;72(3):757-767. doi: 10.1007/s11418-018-1214-x. Epub 2018 Apr 13.
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Botany, ethnomedicines, phytochemistry and pharmacology of Himalayan paeony (Paeonia emodi Royle.).
Ahmad M, Malik K, Tariq A, Zhang G, Yaseen G, Rashid N, Sultana S, Zafar M, Ullah K, Khan MPZ.
J Ethnopharmacol. 2018 Jun 28;220:197-219. doi: 10.1016/j.jep.2018.04.004. Epub 2018 Apr 4. Review.
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Quality Characterization of Japanese Medicinal Paeoniae Radix by Metallomic Analysis.
Shimada-Takaura K, Nakamura Y, Kawase M, Komatsu K, Takahashi K.
Chem Pharm Bull (Tokyo). 2018;66(4):353-357. doi: 10.1248/cpb.c17-00729.
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Variation in Phenolic Content, Profile, and Antioxidant Activity of Seeds among Different Paeoniaostii Cultivated Populations in China.
Zhang XX, Zhang G, Jin M, Niu LX, Zhang YL.
Chem Biodivers. 2018 May;15(5):e1800093. doi: 10.1002/cbdv.201800093. Epub 2018 May 21.
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[Exploration on antibacterial activity and mechanism of flowers and leaves from Paeonia rockii based on network pharmacology].
Bao YT, Wang Y, Ren XD, Huang LF, Zeng R.
Zhongguo Zhong Yao Za Zhi. 2018 Feb;43(4):779-785. doi: 10.19540/j.cnki.cjcmm.2018.0020. Chinese.
PMID: 
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Proteomic analysis of tree peony (Paeonia ostii 'Feng Dan') seed germination affected by low temperature.
Ren XX, Xue JQ, Wang SL, Xue YQ, Zhang P, Jiang HD, Zhang XX.
J Plant Physiol. 2018 May - Jun;224-225:56-67. doi: 10.1016/j.jplph.2017.12.016. Epub 2017 Dec 27.
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Paeoniflorin prevents endoplasmic reticulum stress-associated inflammation in lipopolysaccharide-stimulated human umbilical vein endothelial cells via the IRE1α/NF-κB signaling pathway.
Chen J, Zhang M, Zhu M, Gu J, Song J, Cui L, Liu D, Ning Q, Jia X, Feng L.
Food Funct. 2018 Apr 25;9(4):2386-2397. doi: 10.1039/c7fo01406f.
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Effects of paeoniflorin on neurobehavior, oxidative stress, brain insulin signaling, and synaptic alterations in intracerebroventricular streptozotocin-induced cognitive impairment in mice.
Wang D, Liu L, Li S, Wang C.
Physiol Behav. 2018 Jul 1;191:12-20. doi: 10.1016/j.physbeh.2018.03.016. Epub 2018 Mar 20.
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Screening of Genes Related to Early and Late Flowering in Tree Peony Based on Bulked Segregant RNA Sequencing and Verification by Quantitative Real-Time PCR.
Hou X, Guo Q, Wei W, Guo L, Guo D, Zhang L.
Molecules. 2018 Mar 19;23(3). pii: E689. doi: 10.3390/molecules23030689.
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Population genetic dynamics of Himalayan-Hengduan tree peonies, Paeonia subsect. Delavayanae.
Zhang JM, López-Pujol J, Gong X, Wang HF, Vilatersana R, Zhou SL.
Mol Phylogenet Evol. 2018 Aug;125:62-77. doi: 10.1016/j.ympev.2018.03.003. Epub 2018 Mar 7.
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Paeoniflorin regulates osteoclastogenesis and osteoblastogenesis via manipulating NF-κB signaling pathway both in vitro and in vivo.
Wang Y, Dai J, Zhu Y, Zhong W, Lu S, Chen H, Chai Y.
Oncotarget. 2017 Dec 27;9(7):7372-7388. doi: 10.18632/oncotarget.23677. eCollection 2018 Jan 26.
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Lysophosphatidic acid in medicinal herbs enhances prostaglandin E2 and protects against indomethacin-induced gastric cell damage in vivo and in vitro.
Afroz S, Yagi A, Fujikawa K, Rahman MM, Morito K, Fukuta T, Watanabe S, Kiyokage E, Toida K, Shimizu T, Ishida T, Kogure K, Tokumura A, Tanaka T.
Prostaglandins Other Lipid Mediat. 2018 Mar;135:36-44. doi: 10.1016/j.prostaglandins.2018.01.003. Epub 2018 Feb 17.
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Fatty Acid and Associated Gene Expression Analyses of Three Tree Peony Species Reveal Key Genes for α-Linolenic Acid Synthesis in Seeds.
Zhang QY, Yu R, Xie LH, Rahman MM, Kilaru A, Niu LX, Zhang YL.
Front Plant Sci. 2018 Feb 5;9:106. doi: 10.3389/fpls.2018.00106. eCollection 2018.
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Paeoniflorin Inhibits Receptor Activator for Nuclear Factor κB (RANK) Ligand-Induced Osteoclast Differentiation In Vitro and Particle-Induced Osteolysis In Vivo.
Li Z, Li, Chen X.
Med Sci Monit. 2018 Feb 20;24:1044-1053.
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Paeoniflorin ameliorates collagen-induced arthritis via suppressing nuclear factor-κB signalling pathway in osteoclast differentiation.
Xu H, Cai L, Zhang L, Wang G, Xie R, Jiang Y, Yuan Y, Nie H.
Immunology. 2018 Feb 17. doi: 10.1111/imm.12907. [Epub ahead of print]
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In Vitro and In Vivo Antioxidant Activities of the Flowers and Leaves from Paeonia rockii and Identification of Their Antioxidant Constituents by UHPLC-ESI-HRMSn via Pre-Column DPPH Reaction.
Bao Y, Qu Y, Li J, Li Y, Ren X, Maffucci KG, Li R, Wang Z, Zeng R.
Molecules. 2018 Feb 12;23(2). pii: E392. doi: 10.3390/molecules23020392.
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Daminozide reduces red color intensity in herbaceous peony (Paeonia lactiflora Pall.) flowers by inhibiting the expression of flavonoid biosynthetic genes.
Tang Y, Zhao D, Tao J.
3 Biotech. 2018 Feb;8(2):102. doi: 10.1007/s13205-018-1127-0. Epub 2018 Jan 29.
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Effects of different chemical modifications on the antioxidant activities of polysaccharides sequentially extracted from peony seed dreg.
Li XL, Tu XF, Thakur K, Zhang YS, Zhu DY, Zhang JG, Wei ZJ.
Int J Biol Macromol. 2018 Jun;112:675-685. doi: 10.1016/j.ijbiomac.2018.01.216. Epub 2018 Feb 6.
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Protective effects of a traditional Chinese herbal formula Jiang-Xian HuGan on Concanavalin A-induced mouse hepatitis via NF-κB and Nrf2 signaling pathways.
Tang HH, Li HL, Li YX, You Y, Guan YY, Zhang SL, Liu LX, Bao WL, Zhou Y, Shen XY.
J Ethnopharmacol. 2018 May 10;217:118-125. doi: 10.1016/j.jep.2018.02.003. Epub 2018 Feb 5.
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Interaction between Saikosaponin D, Paeoniflorin, and Human Serum Albumin.
Liang GW, Chen YC, Wang Y, Wang HM, Pan XY, Chen PH, Niu QX.
Molecules. 2018 Jan 27;23(2). pii: E249. doi: 10.3390/molecules23020249.
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Complete Chloroplast Genome Sequence and Phylogenetic Analysis of Paeonia ostii.
Guo S, Guo L, Zhao W, Xu J, Li Y, Zhang X, Shen X, Wu M, Hou X.
Molecules. 2018 Jan 26;23(2). pii: E246. doi: 10.3390/molecules23020246.
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[Polymorphic sites in transcribed spacers of 35S rRNA genes as an indicator of origin of the Paeonia cultivars].
Punina EO, Machs EM, Krapivskaya EE, Rodionov AV.
Genetika. 2017 Feb;53(2):181-91. Russian.
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Total glucosides of paeony suppresses experimental autoimmune uveitis in association with inhibition of Th1 and Th2 cell function in mice.
Huang XT, Wang B, Zhang WH, Peng MQ, Lin D.
Int J Immunopathol Pharmacol. 2018 Jan-Dec;32:394632017751547. doi: 10.1177/0394632017751547.
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Nano-silver modifies the vase life of cut herbaceous peony (Paeonia lactiflora Pall.) flowers.
Zhao D, Cheng M, Tang W, Liu D, Zhou S, Meng J, Tao J.
Protoplasma. 2018 Jul;255(4):1001-1013. doi: 10.1007/s00709-018-1209-1. Epub 2018 Jan 22.
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Polyoxygenated Cyclohexenoids with Promising α-Glycosidase Inhibitory Activity Produced by Phomopsis sp. YE3250, an Endophytic Fungus Derived from Paeonia delavayi.
Huang R, Jiang BG, Li XN, Wang YT, Liu SS, Zheng KX, He J, Wu SH.
J Agric Food Chem. 2018 Feb 7;66(5):1140-1146. doi: 10.1021/acs.jafc.7b04998. Epub 2018 Jan 30.
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Development of Candida albicans Biofilms Is Diminished by Paeonia lactiflora via Obstruction of Cell Adhesion and Cell Lysis.
Lee HS, Kim Y.
J Microbiol Biotechnol. 2018 Mar 28;28(3):482-490. doi: 10.4014/jmb.1712.12041.
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Transcriptomic Analysis Reveals Transcription Factors Related to Leaf Anthocyanin Biosynthesis in Paeonia qiui.
Luo J, Duan J, Huo D, Shi Q, Niu L, Zhang Y.
Molecules. 2017 Dec 8;22(12). pii: E2186. doi: 10.3390/molecules22122186.
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Paeoniflorin inhibits proliferation of endometrial cancer cells via activating MAPK and NF-κB signaling pathways.
Zhang J, Wang F, Wang H, Wang Y, Wu Y, Xu H, Su C.
Exp Ther Med. 2017 Dec;14(6):5445-5451. doi: 10.3892/etm.2017.5250. Epub 2017 Oct 2.
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Mining and expression analysis of candidate genes involved in regulating the chilling requirement fulfillment of Paeonia lactiflora 'Hang Baishao'.
Zhang J, Li D, Shi X, Zhang D, Qiu S, Wei J, Zhang J, Zhou J, Zhu K, Xia Y.
BMC Plant Biol. 2017 Dec 22;17(1):262. doi: 10.1186/s12870-017-1205-1.
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Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposure times.
Oh SM, Park G, Lee SH, Seo CS, Shin HK, Oh DS.
BMC Complement Altern Med. 2017 Dec 19;17(1):544. doi: 10.1186/s12906-017-2055-y.
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[Growth rings in roots of seven Sect. Paeonia species and its application on identification of Paeoniae Radix Rubra].
Chu SS, Zha LP, Duan HY, Xu T, Peng HS.
Zhongguo Zhong Yao Za Zhi. 2017 Oct;42(19):3723-3727. doi: 10.19540/j.cnki.cjcmm.2017.0147. Chinese.
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Neuroprotective Effect of Modified Xijiao Dihuang Decoction against Oxygen-Glucose Deprivation and Reoxygenation-Induced Injury in PC12 Cells: Involvement of TLR4-MyD88/NF-κB Signaling Pathway.
Zhang X, Fei X, Tao W, Li J, Shen H, Wang X, Liu H, Xu Y.
Evid Based Complement Alternat Med. 2017;2017:3848595. doi: 10.1155/2017/3848595. Epub 2017 Oct 30.
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EGHB010, a Standardized Extract of Paeoniae Radix and Glycyrrhizae Radix, Inhibits VEGF-Induced Tube Formation In Vitro and Retinal Vascular Leakage and Choroidal Neovascularization In Vivo.
Jung E, Jung W, Park SB, Kim CS, Kim JS, Kim J.
Evid Based Complement Alternat Med. 2017;2017:1568702. doi: 10.1155/2017/1568702. Epub 2017 Oct 4.
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Transcriptome sequencing of Paeonia suffruticosa 'Shima Nishiki' to identify differentially expressed genes mediating double-color formation.
Zhang X, Zhao L, Xu Z, Yu X.
Plant Physiol Biochem. 2018 Feb;123:114-124. doi: 10.1016/j.plaphy.2017.12.009. Epub 2017 Dec 8.
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Phytochemical variation among the traditional Chinese medicine Mu Dan Pi from Paeoniasuffruticosa (tree peony).
Li SS, Wu Q, Yin DD, Feng CY, Liu ZA, Wang LS.
Phytochemistry. 2018 Feb;146:16-24. doi: 10.1016/j.phytochem.2017.11.008. Epub 2017 Dec 22.
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Paeoniflorin inhibits PDGF BB induced human airway smooth muscle cell growth and migration.
Zhou H, Wu Q, Wei L, Peng S.
Mol Med Rep. 2018 Feb;17(2):2660-2664. doi: 10.3892/mmr.2017.8180. Epub 2017 Nov 29.
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Anti-inflammatory and anti-apoptotic effects of the combination of Ligusticum chuanxiong and Radix Paeoniae against focal cerebral ischaemia via TLR4/MyD88/MAPK/NF-κB signalling pathway in MCAO rats.
Gu J, Su S, Guo J, Zhu Y, Zhao M, Duan JA.
J Pharm Pharmacol. 2018 Feb;70(2):268-277. doi: 10.1111/jphp.12841. Epub 2017 Nov 28.
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Abrupt generalized pustules in patients with rheumatoid arthritis and interstitial lung disease.
Deng W, Miao C, Zhang X.
J Dermatol. 2018 Feb;45(2):198-201. doi: 10.1111/1346-8138.14126. Epub 2017 Nov 23.
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Metabolic study of paeoniflorin and total paeony glucosides from Paeoniae Radix Rubra in rats by high-performance liquid chromatography coupled with sequential mass spectrometry.
Zhu L, Sun S, Hu Y, Liu Y.
Biomed Chromatogr. 2018 Apr;32(4). doi: 10.1002/bmc.4141. Epub 2018 Jan 19.
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[Next generation sequencing and transcriptome analysis of root bark from Paeonia suffruticosa cv. Feng Dan].
Xie DM, Yu NJ, Huang LQ, Peng DY, Liu CB, Zhu YJ, Huang H.
Zhongguo Zhong Yao Za Zhi. 2017 Aug;42(15):2954-2961. doi: 10.19540/j.cnki.cjcmm.20170714.001. Chinese.
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Simultaneous determination of saikosaponin a, paeonol, and imperatorin, components of DA-9805, in rat plasma by LC-MS/MS and application to a pharmacokinetic study.
Kwon MH, Jeong JS, Ryu J, Cho YW, Kang HE.
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:289-296. doi: 10.1016/j.jchromb.2017.10.059. Epub 2017 Nov 4.
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Peptide Nucleic Acid Based Molecular Authentication for Identification of Four Medicinal PaeoniaSpecies Using Melting Array Analysis of the Internal Transcribed Spacer 2 Region.
Kim WJ, Yang S, Choi G, Moon BC.
Molecules. 2017 Nov 7;22(11). pii: E1922. doi: 10.3390/molecules22111922.
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Characterization of molecular signature of the roots of Paeonia lactiflora during growth.
Liu P, Xu Y, Yan H, Chen J, Shang EX, Qian DW, Jiang S, Duan JA.
Chin J Nat Med. 2017 Oct;15(10):785-793. doi: 10.1016/S1875-5364(17)30110-3.
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[Research and investigation on original plants of medicinal Moutan].
Peng HS, Wang DQ, Peng DY, Huang LQ.
Zhongguo Zhong Yao Za Zhi. 2017 May;42(9):1632-1636. doi: 10.19540/j.cnki.cjcmm.2017.0064. Chinese.
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Chemical Profile and Antioxidant Activity of the Oil from Peony Seeds (Paeonia suffruticosa Andr.).
Yang X, Zhang D, Song LM, Xu Q, Li H, Xu H.
Oxid Med Cell Longev. 2017;2017:9164905. doi: 10.1155/2017/9164905. Epub 2017 Sep 26.
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Effects of sulfur-fumigation on the pharmacokinetics, metabolites and analgesic activity of Radix Paeoniae Alba.
Kong M, Liu HH, Wu J, Shen MQ, Wang ZG, Duan SM, Zhang YB, Zhu H, Li SL.
J Ethnopharmacol. 2018 Feb 15;212:95-105. doi: 10.1016/j.jep.2017.10.023. Epub 2017 Nov 5.
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Hepatoprotective effect of peony total glucosides and the underlying mechanisms in diabetic rats.
Xia LL, Zhu QJ, Wu YG.
Pharm Biol. 2017 Dec;55(1):2178-2187. doi: 10.1080/13880209.2017.1390589.
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Overexpression of herbaceous peony miR156e-3p improves anthocyanin accumulation in transgenic Arabidopsis thaliana lateral branches.
Zhao D, Xia X, Wei M, Sun J, Meng J, Tao J.
3 Biotech. 2017 Dec;7(6):379. doi: 10.1007/s13205-017-1011-3. Epub 2017 Oct 23.
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Discovery of α-l-arabinopyranosidases from human gut microbiome expands the diversity within glycoside hydrolase family 42.
Viborg AH, Katayama T, Arakawa T, Abou Hachem M, Lo Leggio L, Kitaoka M, Svensson B, Fushinobu S.
J Biol Chem. 2017 Dec 22;292(51):21092-21101. doi: 10.1074/jbc.M117.792598. Epub 2017 Oct 23.
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[Clinical efficacy and mechanism of total glucosides from white paeony for radioactive liver damage].
Gao SL, Hu ZT, Dong LY, Fei ZL, Ma JK, Liu JY.
Zhongguo Zhong Yao Za Zhi. 2017 Apr;42(7):1390-1394. doi: 10.19540/j.cnki.cjcmm.20170121.040. Chinese.
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PrLPAAT4, a Putative Lysophosphatidic Acid Acyltransferase from Paeonia rockii, Plays an Important Role in Seed Fatty Acid Biosynthesis.
Zhang Q, Yu R, Sun D, Bai Z, Li H, Xue L, Zhang Y, Niu L.
Molecules. 2017 Oct 10;22(10). pii: E1694. doi: 10.3390/molecules22101694.
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[Treatment of cardiovascular disease with Xiongshao capsule].
Yuan R, Wang Y, Cong WH, Chen KJ.
Zhongguo Zhong Yao Za Zhi. 2017 Feb;42(4):640-643. doi: 10.19540/j.cnki.cjcmm.2017.0017. Review. Chinese.
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Physicochemical characteristics and functionality of tree peony (Paeonia suffruticosa Andr.) seed protein.
Gao LL, Li YQ, Wang ZS, Sun GJ, Qi XM, Mo HZ.
Food Chem. 2018 Feb 1;240:980-988. doi: 10.1016/j.foodchem.2017.07.124. Epub 2017 Jul 25.
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Systematic characterization of the metabolites of paeonol in rats using ultra performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight tandem mass spectrometry with an integrative strategy.
Ding LQ, Qiu TY, Liu ZX, Chen LX, Oppong MB, Zhang DQ, Zhang BL, Bai G, Qiu F.
J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Oct 15;1065-1066:70-78. doi: 10.1016/j.jchromb.2017.09.015. Epub 2017 Sep 11.
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Total glucosides of paeony ameliorates TNBS induced colitis by modulating differentiation of Th17/Treg cells and the secretion of cytokines.
Lin H, Zhang W, Jiang X, Chen R, Huang X, Huang Z.
Mol Med Rep. 2017 Dec;16(6):8265-8276. doi: 10.3892/mmr.2017.7598. Epub 2017 Sep 25.
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Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry.
Behrendt P, Perin P, Menzel N, Banda D, Pfaender S, Alves MP, Thiel V, Meuleman P, Colpitts CC, Schang LM, Vondran FWR, Anggakusuma, Manns MP, Steinmann E, Pietschmann T.
Antiviral Res. 2017 Nov;147:19-28. doi: 10.1016/j.antiviral.2017.09.006. Epub 2017 Sep 18.
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Total glucosides of paeony for rheumatoid arthritis: A systematic review of randomized controlled trials.
Luo J, Jin DE, Yang GY, Zhang YZ, Wang JM, Kong WP, Tao QW.
Complement Ther Med. 2017 Oct;34:46-56. doi: 10.1016/j.ctim.2017.07.010. Epub 2017 Jul 26. Review.
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Nephroprotective effect of Paeonia emodi via inhibition of advanced glycation end products and oxidative stress in streptozotocin-nicotinamide induced diabetic nephropathy.
Kishore L, Kaur N, Singh R.
J Food Drug Anal. 2017 Jul;25(3):576-588. doi: 10.1016/j.jfda.2016.08.009. Epub 2016 Nov 11.
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Probing the Molecular Mechanisms Governing the Oncolytic Activity of Paeonia suffruticosa on Triple-negative Breast Cancer Cells In Vitro.
Kim D, Radin D, Leonardi D.
Anticancer Res. 2017 Sep;37(9):4813-4819.
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Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression.
Li Y, Gong L, Qi R, Sun Q, Xia X, He H, Ren J, Zhu O, Zhuo D.
Drug Des Devel Ther. 2017 Aug 23;11:2481-2491. doi: 10.2147/DDDT.S134518. eCollection 2017.
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Screening, separation, and evaluation of xanthine oxidase inhibitors from Paeonia lactiflora using chromatography combined with a multi-mode microplate reader.
Wang J, Shi D, Zheng M, Ma B, Cui J, Liu C, Liu C.
J Sep Sci. 2017 Nov;40(21):4160-4167. doi: 10.1002/jssc.201700690. Epub 2017 Sep 25.
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Total glycosides of Paeony shows Neuroprotective effects against Semen Strychni-induced neurotoxicity by recovering secretion of hormones and improving brain energy metabolism.
Hou C, Zhang R, Zhang K, Chen X.
Metab Brain Dis. 2017 Dec;32(6):2033-2044. doi: 10.1007/s11011-017-0082-5. Epub 2017 Aug 29.
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Botrytis euroamericana, a new species from peony and grape in North America and Europe.
Garfinkel AR, Lorenzini M, Zapparoli G, Chastagner GA.
Mycologia. 2017 May-Jun;109(3):495-507. doi: 10.1080/00275514.2017.1354169. Epub 2017 Jul 19.
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Transcriptome Analysis of Two Different Developmental Stages of Paeonia lactiflora Seeds.
Ma Y, Cui J, Lu X, Zhang L, Chen Z, Fei R, Sun X.
Int J Genomics. 2017;2017:8027626. doi: 10.1155/2017/8027626. Epub 2017 Aug 7.
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Efficacy of Topical Compound Danxiong Granules for Treatment of Dermatologic Toxicities Induced by Targeted Anticancer Therapy: A Randomized, Double-Blind, Placebo-Controlled Trial.
Tian A, Zhou A, Bi X, Hu S, Jiang Z, Zhang W, Huang Z, Shi H, Yang B, Chen W.
Evid Based Complement Alternat Med. 2017;2017:3970601. doi: 10.1155/2017/3970601. Epub 2017 Aug 6.
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Capture of anti-coagulant active ingredients from Moutan Cortex by platelet immobilized chromatography and evaluation of anticoagulant activity in rats.
Qiu H, Zhang L, Zhu M, Zhang M, Chen J, Feng L, Jia X, Jacob JA.
Biomed Pharmacother. 2017 Nov;95:235-244. doi: 10.1016/j.biopha.2017.08.051. Epub 2017 Sep 12.
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[Analyze moisture transformation and transport rules during processing of Paeoniae Radix Alba by using low-field NMR].
Duan WJ, Li Y, Cui L, Liu F, Yang GH, Guo LP, Wang X.
Zhongguo Zhong Yao Za Zhi. 2017 Jun;42(11):2092-2096. doi: 10.19540/j.cnki.cjcmm.20170415.004. Chinese.
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Biochemical and Comparative Transcriptomic Analyses Identify Candidate Genes Related to Variegation Formation in Paeonia rockii.
Shi Q, Li L, Zhang X, Luo J, Li X, Zhai L, He L, Zhang Y.
Molecules. 2017 Aug 17;22(8). pii: E1364. doi: 10.3390/molecules22081364.
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Apoptotic Effect of Astragalin in Melanoma Skin Cancers via Activation of Caspases and Inhibition of Sry-related HMg-Box Gene 10.
You OH, Shin EA, Lee H, Kim JH, Sim DY, Kim JH, Kim Y, Khil JH, Baek NI, Kim SH.
Phytother Res. 2017 Oct;31(10):1614-1620. doi: 10.1002/ptr.5895. Epub 2017 Aug 15.
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Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells.
Zhang ZH, Xie DD, Xu S, Xia MZ, Zhang ZQ, Geng H, Chen L, Wang DM, Wei W, Yu DX, Xu DX.
PLoS One. 2017 Aug 4;12(8):e0182584. doi: 10.1371/journal.pone.0182584. eCollection 2017.
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Systems Pharmacology Dissection of Multiscale Mechanisms of Action for Herbal Medicines in Treating Rheumatoid Arthritis.
Wang J, Li Y, Yang Y, Du J, Zhao M, Lin F, Zhang S, Wang B.
Mol Pharm. 2017 Sep 5;14(9):3201-3217. doi: 10.1021/acs.molpharmaceut.7b00505. Epub 2017 Aug 22.
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Evaluation of ITS2 for intraspecific identification of Paeonia lactiflora cultivars.
Li Q, Xu J, Han L, Gao C, Lu J, Du G, Sun X.
Biotechnol Rep (Amst). 2017 Jul 8;15:101-106. doi: 10.1016/j.btre.2017.07.003. eCollection 2017 Sep.
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A systemic review and meta-analysis of the clinical efficacy and safety of total glucosides of peony combined with methotrexate in rheumatoid arthritis.
Feng ZT, Xu J, He GC, Cai SJ, Li J, Mei ZG.
Clin Rheumatol. 2018 Jan;37(1):35-42. doi: 10.1007/s10067-017-3770-y. Epub 2017 Jul 27. Review.
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The Potential Impact of Radix Paeoniae Alba in Embryonic Development of Mice.
Xu W, Xu L, Deng B, Leng J, Tang N, Zhao LC, Zhou HH, Zhao ZZ, Yang ZJ, Xiao TT, Tian XY, Ho AHM, Chan NWK, Chow YL, Chow CY, Xu M.
Phytother Res. 2017 Sep;31(9):1376-1383. doi: 10.1002/ptr.5864. Epub 2017 Jul 21.
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Genetic analyses reveal independent domestication origins of the emerging oil crop Paeonia ostii, a tree peony with a long-term cultivation history.
Peng LP, Cai CF, Zhong Y, Xu XX, Xian HL, Cheng FY, Mao JF.
Sci Rep. 2017 Jul 13;7(1):5340. doi: 10.1038/s41598-017-04744-z.
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Effects of an Enriched Extract of Paeoniflorin, a Monoterpene Glycoside used in Chinese Herbal Medicine, on Cholesterol Metabolism in a Hyperlipidemic Rat Model.
Hu H, Zhu Q, Su J, Wu Y, Zhu Y, Wang Y, Fang H, Pang M, Li B, Chen S, Lv G.
Med Sci Monit. 2017 Jul 14;23:3412-3427.
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Paeonol Inhibits IL-1β-Induced Inflammation via PI3K/Akt/NF-κB Pathways: In Vivo and Vitro Studies.
Lou Y, Wang C, Tang Q, Zheng W, Feng Z, Yu X, Guo X, Wang J.
Inflammation. 2017 Oct;40(5):1698-1706. doi: 10.1007/s10753-017-0611-8.
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Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial.
Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, Bensoussan A.
Phytother Res. 2017 Sep;31(9):1330-1340. doi: 10.1002/ptr.5858. Epub 2017 Jul 7.
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Chemical Compositions and Antioxidant Activities of Essential Oils Extracted from the Petals of Three Wild Tree Peony Species and Eleven Cultivars.
Zhang XX, Sun JY, Niu LX, Zhang YL.
Chem Biodivers. 2017 Nov;14(11). doi: 10.1002/cbdv.201700282. Epub 2017 Oct 30.
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Protective effects of paeoniflorin on TNBS-induced ulcerative colitis through inhibiting NF-kappaB pathway and apoptosis in mice.
Gu P, Zhu L, Liu Y, Zhang L, Liu J, Shen H.
Int Immunopharmacol. 2017 Sep;50:152-160. doi: 10.1016/j.intimp.2017.06.022. Epub 2017 Jun 27.
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Efficacy and Safety of GuiZhi-ShaoYao-ZhiMu Decoction for Treating Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Daily JW, Zhang T, Cao S, Park S.
J Altern Complement Med. 2017 Oct;23(10):756-770. doi: 10.1089/acm.2017.0098. Epub 2017 Jun 13. Review.
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Illumina-based analysis of endophytic bacterial diversity of tree peony (Paeonia Sect. Moutan) roots and leaves.
Yang R, Liu P, Ye W.
Braz J Microbiol. 2017 Oct - Dec;48(4):695-705. doi: 10.1016/j.bjm.2017.02.009. Epub 2017 Jun 2.
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Anti-proliferative and anti-metastasis effects of ten oligostilbenes from the seeds of Paeoniasuffruticosa on human cancer cells.
Gao Y, He C.
Oncol Lett. 2017 Jun;13(6):4371-4377. doi: 10.3892/ol.2017.5982. Epub 2017 Apr 4.
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Origins, Phytochemistry, Pharmacology, Analytical Methods and Safety of Cortex Moutan (Paeoniasuffruticosa Andrew): A Systematic Review.
Wang Z, He C, Peng Y, Chen F, Xiao P.
Molecules. 2017 Jun 7;22(6). pii: E946. doi: 10.3390/molecules22060946. Review.
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Determination of the phenolic content, profile, and antioxidant activity of seeds from nine tree peony (Paeonia section Moutan DC.) species native to China.
Zhang XX, Shi QQ, Ji D, Niu LX, Zhang YL.
Food Res Int. 2017 Jul;97:141-148. doi: 10.1016/j.foodres.2017.03.018. Epub 2017 Mar 15.
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Moutan Cortex Protects Hepatocytes against Oxidative Injury through AMP-Activated Protein Kinase Pathway.
Jang MH, Kim KY, Song PH, Baek SY, Seo HL, Lee EH, Lee SG, Park KI, Ahn SC, Kim SC, Kim YW.
Biol Pharm Bull. 2017;40(6):797-806. doi: 10.1248/bpb.b16-00884.
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Chronic treatment with paeonol improves endothelial function in mice through inhibition of endoplasmic reticulum stress-mediated oxidative stress.
Choy KW, Lau YS, Murugan D, Mustafa MR.
PLoS One. 2017 May 31;12(5):e0178365. doi: 10.1371/journal.pone.0178365. eCollection 2017.
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An herbal formula attenuates collagen-induced arthritis via inhibition of JAK2-STAT3 signaling and regulation of Th17 cells in mice.
Wu X, Shou Q, Chen C, Cai H, Zhang J, Tang S, Cai B, Tang D, Cao G.
Oncotarget. 2017 Jul 4;8(27):44242-44254. doi: 10.18632/oncotarget.17797.
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Heavy metals translocation and accumulation from the rhizosphere soils to the edible parts of the medicinal plant Fengdan (Paeonia ostii) grown on a metal mining area, China.
Shen ZJ, Xu C, Chen YS, Zhang Z.
Ecotoxicol Environ Saf. 2017 Sep;143:19-27. doi: 10.1016/j.ecoenv.2017.04.042. Epub 2017 May 8.
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Quantitative Evaluation of the Compatibility Effects of Huangqin Decoction on the Treatment of Irinotecan-Induced Gastrointestinal Toxicity Using Untargeted Metabolomics.
Cui DN, Wang X, Chen JQ, Lv B, Zhang P, Zhang W, Zhang ZJ, Xu FG.
Front Pharmacol. 2017 Apr 21;8:211. doi: 10.3389/fphar.2017.00211. eCollection 2017.
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In vitro antioxidant and hepatoprotective activities of Paeonia emodi (Wall.) rhizome methanol extract and its phenolic compounds rich fractions.
Ilahi I, Khan J, Ghaffar R, Hussain A, Rahman K, Wahab S, Begum R, Hidayatullah M, Amin A, Sobia -, Shoaib M, Ahmad I, Ali D, Zeb L.
Pak J Pharm Sci. 2016 Sep;29(5 Suppl):1787-1794.
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Anti-Inflammatory Effects, SAR, and Action Mechanism of Monoterpenoids from Radix Paeoniae Alba on LPS-Stimulated RAW 264.7 Cells.
Bi X, Han L, Qu T, Mu Y, Guan P, Qu X, Wang Z, Huang X.
Molecules. 2017 Apr 29;22(5). pii: E715. doi: 10.3390/molecules22050715.
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Paeoniflorin suppressed IL-22 via p38 MAPK pathway and exerts anti-psoriatic effect.
Yu J, Xiao Z, Zhao R, Lu C, Zhang Y.
Life Sci. 2017 Jul 1;180:17-22. doi: 10.1016/j.lfs.2017.04.019. Epub 2017 Apr 26.
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Identification of anti-HBV activities in Paeonia suffruticosa Andr. using GRP78 as a drug target on Herbochip®.
Lam IF, Huang M, Chang MD, Yao PW, Chou YT, Ng SK, Tsai YL, Lin YC, Zhang YF, Yang XY, Lai YK.
Chin Med. 2017 Apr 24;12:11. doi: 10.1186/s13020-017-0132-2. eCollection 2017.
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Application of near-infrared spectroscopy for the rapid quality assessment of Radix Paeoniae Rubra.
Zhan H, Fang J, Tang L, Yang H, Li H, Wang Z, Yang B, Wu H, Fu M.
Spectrochim Acta A Mol Biomol Spectrosc. 2017 Aug 5;183:75-83. doi: 10.1016/j.saa.2017.04.034. Epub 2017 Apr 20.
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Identification of bioactive compounds in Shaoyao-Gancao decoction using β2-adrenoceptor affinity chromatography.
Li Z, Gao H, Li J, Zhang Y.
J Sep Sci. 2017 Jun;40(12):2558-2564. doi: 10.1002/jssc.201700113. Epub 2017 May 11.
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Effects of Paeonia emodi on hepatic cytochrome P450 (CYP3A2 and CYP2C11) expression and pharmacokinetics of carbamazepine in rats.
Raish M, Ahmad A, Alkharfy KM, Jan BL, Mohsin K, Ahad A, Al-Jenoobi FI, Al-Mohizea AM.
Biomed Pharmacother. 2017 Jun;90:694-698. doi: 10.1016/j.biopha.2017.04.015. Epub 2017 Apr 15.
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Moutan Cortex and Paeoniae Radix Rubra reverse high-fat-diet-induced metabolic disorder and restore gut microbiota homeostasis.
Zhong LJ, Xie ZS, Yang H, Li P, Xu XJ.
Chin J Nat Med. 2017 Mar;15(3):210-219. doi: 10.1016/S1875-5364(17)30037-7.
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Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol.
Liu MH, Lin AH, Ko HK, Perng DW, Lee TS, Kou YR.
Front Physiol. 2017 Mar 31;8:193. doi: 10.3389/fphys.2017.00193. eCollection 2017.
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Effects of Trang Phuc Linh Plus-Food Supplement on Irritable Bowel Syndrome Induced by Mustard Oil.
Nguyen TT, Dau DT, Nguyen DC, Nguyen HT, Ngo PT, Nguyen TQ, Han B, Hoang BX.
J Med Food. 2017 Apr;20(4):385-391. doi: 10.1089/jmf.2016.0129.
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Efficacy and safety of total glucosides of paeony combined with acitretin in the treatment of moderate-to-severe plaque psoriasis: a double-blind, randomised, placebo-controlled trial.
Yu C, Fan X, Li Z, Liu X, Wang G.
Eur J Dermatol. 2017 Apr 1;27(2):150-154. doi: 10.1684/ejd.2016.2946.
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Analysis of chemical constituents in an herbal formula Jitong Ning Tablet.
Gao D, Wang B, Huo Z, He Y, Polachi N, Lei Z, Liu X, Song Z, Qi LW.
J Pharm Biomed Anal. 2017 Jun 5;140:301-312. doi: 10.1016/j.jpba.2017.03.033. Epub 2017 Mar 19.
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Aromatic monoterpenoid glycosides from the seeds of Paeonia ostii.
Qin JJ, Mao YY, Li JL, Guan Y, Zhao WM.
J Asian Nat Prod Res. 2017 Dec;19(12):1149-1154. doi: 10.1080/10286020.2017.1307191. Epub 2017 Apr 5.
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Phenolic compounds, antioxidant potential and antiproliferative potential of 10 common edible flowers from China assessed using a simulated in vitro digestion-dialysis process combined with cellular assays.
Huang W, Mao S, Zhang L, Lu B, Zheng L, Zhou F, Zhao Y, Li M.
J Sci Food Agric. 2017 Nov;97(14):4760-4769. doi: 10.1002/jsfa.8345. Epub 2017 May 4.
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Paeoniflorin attenuates the neuroinflammatory response in a rat model of chronic constriction injury.
Zhou J, Wang J, Li W, Wang C, Wu L, Zhang J.
Mol Med Rep. 2017 May;15(5):3179-3185. doi: 10.3892/mmr.2017.6371. Epub 2017 Mar 24.
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Thermal analysis during partial carbonizing process of rhubarb, moutan and burnet.
Ma J, Meng X, Guo X, Lan Y, Zhang S.
PLoS One. 2017 Mar 21;12(3):e0173946. doi: 10.1371/journal.pone.0173946. eCollection 2017.
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Paeoniflorin ameliorates cognitive dysfunction via regulating SOCS2/IRS-1 pathway in diabetic rats.
Sun X, Li S, Xu L, Wang H, Ma Z, Fu Q, Qu R, Ma S.
Physiol Behav. 2017 May 15;174:162-169. doi: 10.1016/j.physbeh.2017.03.020. Epub 2017 Mar 16.
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